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Understand the
definitions and usage of common scientific terms in proteomics by
browsing this Glossary from the Proteome Society®.
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| A | B
| C | D
| E | F
| G | H
| I | J | K | L
| M | N
| O | P
| Q |
R | S
| T | U
| V |
W | X | Y | Z
F
Family
Set of proteins that share a common evolutionary origin reflected
by their relatedness in function which is usually reflected by similarities
in primary, secondary or tertiary structure. Can be ambiguous, but
typically >50% identity
FAQ
Frequently asked questions
FASTA
An alignment program for protein sequences created by Pearson and
Lipman in 1988. The program is one of the many heuristic algorithms
proposed to speed up sequence comparison. The basic idea is to add
a fast prescreen step to locate the highly matching segments between
two sequences, and then extend these matching segments to local
alignments using more rigorous algorithms such as Smith-Waterman.
Feature
Annotation on a specific location on a given sequence.
Federated
database
An integrated repository data from of multiple, possibly heterogeneous,
data sources presented with consistent and coherent semantics.
Femtomole
10-15 mole
TOP
FindMod
ExPASy tool that predicts post-translational modifications to proteins
based on mass differences between experimental and computed fingerprints.
Flat
file
A text file that structures the information in a simple format using
tags. Typically consists of a header, features, and a sequence.
Fractionation
Division of a sample into two or more fractions to decrease complexity
before analysis
FTICR
Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, a high
resolution sensitivity MS technique
FTP
File
transfer protocol; the method by which files are transferred.
TOP
G
Gap penalty
The penalty applied to a similarity score for the introduction of
an insertion or deletion gap, the extension of a gap, or both. Gap
penalties are usually subtracted from a cumulative score being determined
for the comparison of two or more sequences via an optimization algorithm
that attempts to maximize that score.
Gene
DNA segment that contains the genetic code for producing a protein
GlycoMod
ExPASy tool that predicts oligosaccharide modifications from mass
differences.
Gopher
A document delivery system for retrieval and display of text-based
files.
Gradient
drift
Instability of a pH gradient formed in free solution electrophoresis
Gradient
gels
Polyacrylamide gels with a specified range of crosslinking
TOP
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